The laborers of the cell. Wonderfully complex. Discovering medicines will require a systematic approach.
Molecular
Machines
Major advancements in genetics and functional genomics have uncovered molecular machines as drivers of disease.
In cancer, a tumor’s genetic make-up can lead to dependence on the activity of one molecular machine for growth and survival. In rare genetic disorders, point mutations in the machines themselves can lead to disrupted or altered function.
Molecular machines present compelling therapeutic opportunities to transform the lives of patients.
Force, work and motion.
Molecular machines are enzymes that create force, work, and motion.
There are over 400 proteins in the molecular machine family and they govern diverse processes within cells. DNA replication and repair, biomolecular transport and protein homeostasis to name a few.
Their enzymatic output depends on the machines cycling through a series of ordered and large-scale conformational changes.
The time for
MOMA is now.
The technologies exist for us to take on molecular machines.
Our biomechanics engine brings together world-class expertise in biochemistry, biophysics, structural biology, computation, chemistry, and functional genomics.
The time for
MOMA is now.
The technologies exist for us to take on molecular machines.
Our biomechanics engine brings together world-class expertise in biochemistry, biophysics, structural biology, computation, chemistry, and functional genomics.
MOMA is unique in its singular focus.
A concentration on only molecular machines ensures that our entire R&D organization is built to tackle the unique challenges and opportunities inherent to this class.
Each component of our discovery platform is being developed and optimized for the sole purpose of drugging this class of enzymes.
MOMA is unique in its singular focus.
A concentration on only molecular machines ensures that our entire R&D organization is built to tackle the unique challenges and opportunities inherent to this class.
Each component of our discovery platform is being developed and optimized for the sole purpose of drugging this class of enzymes.
We are purposefully systematizing our approach.
Target class-focused research enables a continuous learning loop, creating more streamlined workflows and directed activities which increase in sophistication and efficiency over time.
We will establish a fit-for-purpose drug discovery platform that unlocks the potential of the molecular machines.
We are purposefully systematizing our approach.
Target class-focused research enables a continuous learning loop, creating more streamlined workflows and directed activities which increase in sophistication and efficiency over time.
We will establish a fit-for-purpose drug discovery platform that unlocks the potential of the molecular machines.
If you want to get to know us, you need to understand what makes us tick.
MOMA