Archive for Publications

Human polymerase θ helicase positions DNA microhomologies for double-strand break repair

Published in Nature Structural & Molecular Biology on February 28, 2025, Human polymerase θ helicase positions DNA microhomologies for double-strand break repair, authored by Christopher J. Zerio, Yonghong Bai, Brian A. Sosa-Alvarado, Timothy Guzi & Gabriel C. Lander marks…

MOMA-313 is a potent, selective Polθ inhibitor that enhances response to PARP inhibition in HR-deficient tumor models

MOMA Therapeutics is pleased to be attending this year’s EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics in Barcelona, Spain. Our Vice President, Biology and Translational Sciences, Erica Evans, will…