Published in Nature Structural & Molecular Biology on February 28, 2025, Human polymerase θ helicase positions DNA microhomologies for double-strand break repair, authored by Christopher J. Zerio, Yonghong Bai, Brian A. Sosa-Alvarado, Timothy Guzi & Gabriel C. Lander marks a significant advancement in our understanding of the Pol-theta mechanism, providing insights into how Pol-theta performs DNA repair.